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In 2007, Savage and West extended this work using mathematical modeling to demonstrate that sleep duration correlates more strongly with brain metabolic rate than whole-body metabolic rate, reinforcing the hypothesis that sleep need is primarily driven by the brains metabolic and restorative demands (Savage and West, 2007)

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The combined acupunctureTCM approach yielded greater reductions in tinnitus severity and intensity and more favorable modulation of 5-HT and GABA levels than the standard therapy

Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors

rather, it constitutes a metabolically active biochemical processing center that enzymatically biotransforms xenobiotics and endogenous toxins through highly regulated, pathway-specific metabolic processes